Just a few decades ago smoking was a wide spread habit. Today, thanks to the comprehensive knowledge we have about the effects of smoking on health, smoking is considered a very unhealthy habit that threatens life.

This awareness of the many serious health problems it causes, shortening and affecting the quality of life, along with the tightening of regulatory laws prohibiting smoking in shared public spaces, makes more and more people want to kick the habit.

Quitting smoking is a difficult task, but not impossible. Those who want to quit know they face a tough process, because we are talking about an addiction. But to reach that goal there is a difficult path ahead of every smoker. During the process of quitting, the body reacts to this new situation, producing a series of alterations and changes at all levels which are transient, but sometimes very annoying. This passage is feared by many people who quit smoking and it often affects the very motivation to continue. Common problems are mood swings, irritability, anxiety and insomnia.

Can melatonin help ease the process of quitting?

Melatonin in the process of quitting smoking has a very important role because it helps fight insomnia which usually appears at the beginning, helping to restore a high quality sleep in a natural way. Melatonin, unlike sleeping pills, is not addictive and does not have undesirable side effects of drugs. In addition, melatonin can bring serenity, because a good night’s sleep itself exerts a certain anxiolytic effect, helping to improve this state of anxiety and irritability that often accompanies quitting.

Melatonin: fighting the vascular damage caused by nicotine

Nicotine is responsible for much of the vascular damage caused by smoking. Nicotine causes structural and functional changes in the blood vessels, which result in cardiovascular disease, damaging the vessels, causing vasoconstriction and oxidative stress and aging of all cells.
The benefits of melatonin on cardiovascular problems are well-known. Now researchers want to find out the role of melatonin as a therapeutic tool to combat such diseases directly caused by nicotine. In this regard, recent studies have evaluated the effects of melatonin administration on nicotine-induced vasculopathies. The results indicate that melatonin counteracts and improves vascular damage caused by nicotine. They come to the conclusion that taking melatonin should be considered as an interesting therapeutic option to improve vascular damage caused by smoking.

Therefore it can be concluded that melatonin is a powerful weapon that helps fight the undesirable effects when quitting smoking (insomna, irritability, etc. ...). Melatonin also helps to reduce vascular damage caused by smoking and improve vessel health.

Clavis Staff


Naranjo-Rodríguez (2007) Melatonina y Ansiedad. Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México.

Reiter RJ et al (2010) Beneficial effects of melatonin in cardiovascular disease. Ann Med. 2010 May 6;42(4):276-85

Rodella LF et al. (2010). Beneficial effects of melatonin on nicotine-induced vasculopathy. J Pineal Res. 2010 Mar;48(2):126-32. Epub 2009 Dec 30.

Rodella LF et al. (2010). Endothelin-1 as a potential marker of melatonin's therapeutic effects in smoking-induced vasculopathy. Life Sci. 2010 Oct 23;87(17-18):558-64. Epub 2010 Sep 18.

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