Melatonin reduces oxidative stress in traumatic brain



Melatonin reduces traumatic brain injury-induced oxidative stress


Traumatic brain injury can cause post-traumatic neurodegenerations with an increase in reactive oxygen species and reactive oxygen species-mediated lipid peroxidation. Melatonin, a non-enzymatic antioxidant and neuroprotective agent, has been shown to counteract oxidative stress-induced pathophysiologic conditions like cerebral ischemia/reperfusion injury, neuronal excitotoxicity and chronic inflammation. Therefore, the research team at the Neuroscience Research Center, University of Suleyman Demire, led by Prof. Mustafa Naz?ro?lu, aimed to evaluate whether there would be a protective effect of melatonin on oxidative stress and enzymatic and non-enzymatic antioxidant levels in traumatic brain injury rats. Their study released in the Neural Regeneration Research (Vol. 9, No. 11, 2014) have revealed that the cerebral cortex β-carotene, vitamin C, vitamin E, reduced glutathione, and erythrocyte reduced glutathione levels, and plasma vitamin C level were decreased by traumatic brain injury whereas they were increased following melatonin treatment. In conclusion, melatonin seems to have protective effects on traumatic brain injury-induced cerebral cortex and blood toxicity by inhibiting free radical formation and supporting antioxidant vitamin redox system.


 


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Article: "Melatonin reduces traumatic brain injury-induced oxidative stress in the cerebral cortex and blood of rats" by Nilgün ?enol1, Mustafa Naz?ro?lu2 (1 Department of Neurosurgery, Faculty of Medicine, University of Suleyman Demirel, Isparta, Turkey; 2 Neuroscience Research Center, University of Suleyman Demirel, Isparta, Turkey)


?enol N, Naz?ro?lu M. Melatonin reduces traumatic brain injury-induced oxidative stress in the cerebral cortex and blood of rats. Neural Regen Res. 2014;9(11):1112-1116.


Contact: Meng Zhao 
eic@nrren.org 
86-138-049-98773 
Neural Regeneration Research 
http://www.nrronline.org/


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