Night shift working can damage DNA due to the low melatonin production



Working during the night is dangerous: the body can’t fix the damages to DNA.
The causes are connected with the low production of melatonin which regulates di heartbeat. The human body, after the reduction of melatonin, loses the ability to fix the damages to DNA, exposing the subject to the risk of many dangerous diseases. This is what has emerged from a scientific research made by American scientists of the Fred Hutchinson Cancer Research Center of Seattle led by the professor Parveen Bhatti.

Night shift workers are exposed to cellular damages
The scientist , in a previous research, noticed that sleeping during the day reduced the “8-OH-dG” in the urine. The lack of this chemical substance, which is a product derived from the fixing of DNA, indicated a lesser capacity of body to fix the cellular damages. The conclusions has highlighted that the key factor at the base of this difference is the reduced production of the sleep hormone: melatonin.

Lack of melatonin at the origin of the problem
The researchers have measured di 8-OH-dG levels on 50 night shift workers and they noticed important discordances in melatonin level. The analysis confirmed that melatonin level was much more lower in the subjects who work during the night.

Damages to DNA are potentially carcinogenic
“Our results - the Fred Hutchinson Cancer Research Center of Seattle explain- indicate that, differently from the sleep during the night, sleeping during the day causes a reduction of melatonin production, associated to a significant reduction of urine excretion of 8-OH-dG. This problem reflect a reduced ability of body to repair the damages caused by oxidation to DNA due to the insufficient levels of sleep hormone. If these effects will be confirmed during the next researches the supplementation of melatonin could become a solution to use on subject exposed to possible carcinogenic DNA damages.


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