A research made by UBA (University of Buenos Aires) has shown that melatonin can help interrupt or slow down the normal evolution of Alzheimer disease.



Melatonin could help to treat the Alzheimer. A medical research made by the Neuroscience Laboratory of the UBA (University of Buenos Aires) has observed that the assumption of melatonin interrupts the normal evolution of this neurological disease, which begins with some effects on the memory, the senso of orientation and produces a total ageing in few years. "Melatonin doesn't cure Alzheimer, but it has been proved that it produces a significant decrease of the disease progression. Delaying the insurgence of the most dangerous symptoms as the uncontrollable agitation of the patient. Moreover it increases the survival" has revealed the UBA physiology professor Daniel Cardinali.

The discover of the interdisciplinary team of the UBA Neuroscience Laboratory of the physiology Department has motivated to start similar researches in the USA, with a larger number of patients under observation. Nowadays a study analyzing different patients from many specialized centre in the cure of Alzheimer has been conducing, under the supervision of the American Alzheimer Association and another one under the supervision of the National Institute of Health, in which melatonin has been assumed by the patients.

According to what Prof Cardinali explained, the first clue on possible benefits of melatonin in the treatment of patients affected by the Alzheimer disease has been discovered a couple of years ago, starting from the case of two monozygotic twins, who were diagnosed the neurological disease with a 6 months difference, possibly with genetic origin, considering that their mother had suffered the same disease too.

"One of the twins was given melatonin, in order to treat sleep disturbs, which appears while the disease progresses. The other twin wasn't given melatonin. The twin who had been taking melatonin for 4 years and a half not only got better against his problems with sleep, but he still nowadays can live with his wife. On the other hand the other patient died 5 years after the appearance of the disease first symptoms which normally followed its evolution" Cardinali, who has been studying melatonin since 1985, explains "the case of the twins was the first one that suggested us a direct link between Alzheimer and melatonin". The first researches about this case were published in 1998.

Nowadays the Neuroscience laboratory has studied more than 25 people affected by Alzheimer who have been treating with melatonin for 5 years. "All of them have normalized the sleep and a significant reduction of the disease progression". Cardinali continued as he was named by the Journal of Research as 1 of the 3 most productive researchers in the field of melatonin and pineal gland.


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